Assay Detail
Functional
CHEMBL4040204
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Antiviral activity against thymidine kinase deficient Varicella-Zoster virus 07-1 infected in HEL cells assessed as inhibition of plaque formation
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 5.42 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4070180 | — | — | 1 | 7.24 |
| CHEMBL4099787 | — | — | 1 | 7.10 |
| CHEMBL4089642 | — | — | 1 | 6.96 |
| CHEMBL4080837 | — | — | 1 | 5.88 |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 5.28 |
| CHEMBL4073327 | — | — | 1 | 5.08 |
| CHEMBL329554 | — | — | 1 | 4.90 |
| CHEMBL4097362 | — | — | 1 | 4.90 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 4.68 |
| CHEMBL4078094 | — | — | 1 | 4.64 |
| CHEMBL93006 | — | — | 1 | 4.21 |
| CHEMBL4082499 | — | — | 1 | 4.15 |
| CHEMBL4062343 | — | — | 1 | - |
| CHEMBL482465 | — | — | 1 | - |
| CHEMBL4081770 | — | — | 1 | - |
| CHEMBL519667 | — | — | 1 | - |
| CHEMBL270618 | — | — | 1 | - |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
| CHEMBL5314375 | CIDOFOVIR | 4.0 | 1 | - |
| CHEMBL2030736 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4070180 | — | EC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4099787 | — | EC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4089642 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4080837 | — | EC50 | = | 1320.0 | nM | 5.88 |
| CHEMBL31634 | BRIVUDINE | EC50 | = | 5210.0 | nM | 5.28 |
| CHEMBL4073327 | — | EC50 | = | 8240.0 | nM | 5.08 |
| CHEMBL329554 | — | EC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL4097362 | — | EC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL4078094 | — | EC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL93006 | — | EC50 | = | 62300.0 | nM | 4.21 |
| CHEMBL4082499 | — | EC50 | = | 71100.0 | nM | 4.15 |
| CHEMBL4062343 | — | EC50 | > | 356000.0 | nM | - |
| CHEMBL482465 | — | EC50 | > | 328000.0 | nM | - |
| CHEMBL4081770 | — | EC50 | > | 32600.0 | nM | - |
| CHEMBL519667 | — | EC50 | = | 131000.0 | nM | - |
| CHEMBL270618 | — | EC50 | > | 338000.0 | nM | - |
| CHEMBL182 | GANCICLOVIR | EC50 | - | — | - | |
| CHEMBL5314375 | CIDOFOVIR | EC50 | - | — | - | |
| CHEMBL2030736 | — | EC50 | = | 338000.0 | nM | - |