Assay Detail
Functional
CHEMBL4040224
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against CXCR4-tropic HIV-1 NL4-3 infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect after 6 days by XTT dye based assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.31 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.40 |
| CHEMBL4089642 | — | — | 1 | 8.00 |
| CHEMBL4070180 | — | — | 1 | 7.52 |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | 4.0 | 1 | 5.31 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4089642 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4070180 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1486 | TENOFOVIR DISOPROXIL FUMARATE | EC50 | = | 4890.0 | nM | 5.31 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | < | 60.0 | nM | - |