Assay Detail
Binding
CHEMBL4040970
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE2A (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
cGMP-dependent 3',5'-cyclic phosphodiesterase (CHEMBL2652) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.69 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370962 | — | — | 1 | 9.07 |
| CHEMBL3092562 | PF-05180999 | 1.0 | 1 | 9.00 |
| CHEMBL3331521 | — | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370962 | — | IC50 | = | 0.86 | nM | 9.07 |
| CHEMBL3092562 | PF-05180999 | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3331521 | — | IC50 | = | 10.0 | nM | 8.00 |