Assay Detail
Binding
CHEMBL4041092
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-imipramine from human serotonin transporter expressed in HEK-293 cell membranes after 30 mins by scintillation counting
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel 3-(1,2,3,6-Tetrahydropyridin-4-yl)-1H-indole-Based Multifunctional Ligands with Antipsychotic-Like, Mood-Modulating, and Procognitive Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 8.32 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 9.00 |
| CHEMBL4075144 | — | — | 1 | 8.96 |
| CHEMBL4071451 | — | — | 1 | 8.77 |
| CHEMBL4104622 | — | — | 1 | 8.66 |
| CHEMBL4075673 | — | — | 1 | 8.64 |
| CHEMBL4091193 | — | — | 1 | 8.64 |
| CHEMBL4092243 | — | — | 1 | 8.59 |
| CHEMBL4104216 | — | — | 1 | 8.57 |
| CHEMBL4084492 | — | — | 1 | 8.57 |
| CHEMBL4070254 | — | — | 1 | 8.55 |
| CHEMBL4087852 | — | — | 1 | 8.49 |
| CHEMBL4066532 | — | — | 1 | 8.48 |
| CHEMBL4080399 | — | — | 1 | 8.46 |
| CHEMBL4095555 | — | — | 1 | 8.44 |
| CHEMBL4100951 | — | — | 1 | 8.42 |
| CHEMBL4080369 | — | — | 1 | 8.41 |
| CHEMBL4077937 | — | — | 1 | 8.39 |
| CHEMBL4066971 | — | — | 1 | 8.38 |
| CHEMBL4062817 | — | — | 1 | 8.37 |
| CHEMBL4103725 | — | — | 1 | 8.34 |
| CHEMBL4069237 | — | — | 1 | 8.32 |
| CHEMBL4065568 | — | — | 1 | 8.30 |
| CHEMBL4096479 | — | — | 1 | 8.29 |
| CHEMBL4074195 | — | — | 1 | 8.28 |
| CHEMBL4088249 | — | — | 1 | 8.28 |
| CHEMBL4060649 | — | — | 1 | 8.27 |
| CHEMBL4095979 | — | — | 1 | 8.24 |
| CHEMBL4085802 | — | — | 1 | 8.22 |
| CHEMBL4077040 | — | — | 1 | 8.21 |
| CHEMBL4070715 | — | — | 1 | 8.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11 | IMIPRAMINE | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL4075144 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL4071451 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL4104622 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL4075673 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL4091193 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL4092243 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL4104216 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL4084492 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL4070254 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL4087852 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL4066532 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL4080399 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL4095555 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL4100951 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL4080369 | — | Ki | = | 3.9 | nM | 8.41 |
| CHEMBL4077937 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL4066971 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL4062817 | — | Ki | = | 4.3 | nM | 8.37 |
| CHEMBL4103725 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL4069237 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL4065568 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL4096479 | — | Ki | = | 5.1 | nM | 8.29 |
| CHEMBL4074195 | — | Ki | = | 5.2 | nM | 8.28 |
| CHEMBL4088249 | — | Ki | = | 5.3 | nM | 8.28 |
| CHEMBL4060649 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL4095979 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL4085802 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL4077040 | — | Ki | = | 6.2 | nM | 8.21 |
| CHEMBL4070715 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL4078873 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL4067700 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL4088925 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL4099997 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL4079972 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL4104596 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL4081987 | — | Ki | = | 40.0 | nM | 7.40 |