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Assay Detail

CHEMBL4042879

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against CHO cells
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Cricetulus griseus
Cell Type CHO
Confidence 1 — Organism
Curated By Autocuration

Target

CHO (CHEMBL613853)
Type CELL-LINE
Organism Cricetulus griseus

Publication

Synthesis and biological characterisation of ester and amide derivatives of fusidic acid as antiplasmodial agents.
Espinoza-Moraga M, Singh K, Njoroge M, Kaur G, Okombo J, De Kock C, Smith PJ, Wittlin S, Chibale K.
Bioorg Med Chem Lett (2017) 27 : 658 -661
PubMed 28012840 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 27 4.22 6.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL50588 EMETINE 4.0 1 6.75
CHEMBL4099448 1 4.43
CHEMBL4072532 1 4.18
CHEMBL4076105 1 4.14
CHEMBL4067603 1 4.10
CHEMBL4098522 1 4.09
CHEMBL4075052 1 4.06
CHEMBL4076938 1 4.06
CHEMBL4087783 1 4.05
CHEMBL4073226 1 4.05
CHEMBL4087466 1 4.03
CHEMBL4066457 1 4.02
CHEMBL4062455 1 4.02
CHEMBL4095485 1 4.01
CHEMBL4090800 1 4.01
CHEMBL4090915 1 4.00
CHEMBL4083011 1 4.00
CHEMBL4080502 1 4.00
CHEMBL4061132 1 -
CHEMBL4074523 1 -
CHEMBL4066092 1 -
CHEMBL4083635 1 -
CHEMBL4101636 1 -
CHEMBL4093908 1 -
CHEMBL4064641 1 -
CHEMBL4086151 1 -
CHEMBL374975 FUSIDIC ACID 3.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL50588 EMETINE IC50 = 178.0 nM 6.75
CHEMBL4099448 IC50 = 37400.0 nM 4.43
CHEMBL4072532 IC50 = 65500.0 nM 4.18
CHEMBL4076105 IC50 = 71600.0 nM 4.14
CHEMBL4067603 IC50 = 79400.0 nM 4.10
CHEMBL4098522 IC50 = 81900.0 nM 4.09
CHEMBL4075052 IC50 = 87700.0 nM 4.06
CHEMBL4076938 IC50 = 86400.0 nM 4.06
CHEMBL4087783 IC50 = 89400.0 nM 4.05
CHEMBL4073226 IC50 = 89200.0 nM 4.05
CHEMBL4087466 IC50 = 92400.0 nM 4.03
CHEMBL4066457 IC50 = 95300.0 nM 4.02
CHEMBL4062455 IC50 = 95000.0 nM 4.02
CHEMBL4095485 IC50 = 98300.0 nM 4.01
CHEMBL4090800 IC50 = 96700.0 nM 4.01
CHEMBL4090915 IC50 = 99400.0 nM 4.00
CHEMBL4083011 IC50 = 98900.0 nM 4.00
CHEMBL4080502 IC50 = 99700.0 nM 4.00
CHEMBL4061132 IC50 > 155000.0 nM -
CHEMBL4074523 IC50 = 102900.0 nM -
CHEMBL4066092 IC50 > 146000.0 nM -
CHEMBL4083635 IC50 > 140000.0 nM -
CHEMBL4101636 IC50 > 135000.0 nM -
CHEMBL4093908 IC50 > 146000.0 nM -
CHEMBL4064641 IC50 > 140000.0 nM -
CHEMBL4086151 IC50 > 135000.0 nM -
CHEMBL374975 FUSIDIC ACID IC50 > 194000.0 nM -