Assay Detail
Binding
CHEMBL4044384
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ovine COX-1 preincubated for 5 mins followed by arachidonic acid substrate addition by colorimetric enzyme immunoassay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Ovis aries |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of some novel indolizine derivatives as dual cyclooxygenase and lipoxygenase inhibitor for anti-inflammatory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.26 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | 6.82 |
| CHEMBL300982 | LICOFELONE | 2.0 | 1 | 6.80 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.17 |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | - |
| CHEMBL4075687 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139 | DICLOFENAC | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL300982 | LICOFELONE | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL118 | CELECOXIB | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL93 | ZILEUTON | IC50 | - | — | - | |
| CHEMBL4075687 | — | IC50 | > | 50000.0 | nM | - |