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Assay Detail

CHEMBL4044826

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against wild type thymidine kinase-deficient Varicella-Zoster virus 07-1 infected in HEL cells assessed as inhibition of virus-induced plaque formation
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human alphaherpesvirus 3
Confidence 1 — Organism
Curated By Autocuration

Target

Human alphaherpesvirus 3 (CHEMBL613132)
Type ORGANISM
Organism Human alphaherpesvirus 3

Publication

New prodrugs of two pyrimidine acyclic nucleoside phosphonates: Synthesis and antiviral activity.
Krečmerová M, Dračínský M, Snoeck R, Balzarini J, Pomeisl K, Andrei G.
Bioorg Med Chem (2017) 25 : 4637 -4648
PubMed 28757102 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 20 5.25 6.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4072751 1 6.54
CHEMBL4101168 1 6.54
CHEMBL4093465 1 6.10
CHEMBL4103271 1 5.90
CHEMBL4071676 1 5.88
CHEMBL1823516 1 5.77
CHEMBL298845 1 5.33
CHEMBL4074426 1 5.23
CHEMBL4063056 1 4.63
CHEMBL4082206 1 4.57
CHEMBL184 ACYCLOVIR 4.0 1 4.41
CHEMBL4092474 1 4.31
CHEMBL31634 BRIVUDINE 2.0 1 4.23
CHEMBL4064156 1 4.00
CHEMBL5314375 CIDOFOVIR 4.0 1 -
CHEMBL182 GANCICLOVIR 4.0 1 -
CHEMBL4085723 1 -
CHEMBL4090051 1 -
CHEMBL4062012 1 -
CHEMBL4100217 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4072751 EC50 = 290.0 nM 6.54
CHEMBL4101168 EC50 = 290.0 nM 6.54
CHEMBL4093465 EC50 = 790.0 nM 6.10
CHEMBL4103271 EC50 = 1260.0 nM 5.90
CHEMBL4071676 EC50 = 1320.0 nM 5.88
CHEMBL1823516 EC50 = 1690.0 nM 5.77
CHEMBL298845 EC50 = 4720.0 nM 5.33
CHEMBL4074426 EC50 = 5910.0 nM 5.23
CHEMBL4063056 EC50 = 23200.0 nM 4.63
CHEMBL4082206 EC50 = 26800.0 nM 4.57
CHEMBL184 ACYCLOVIR EC50 = 38900.0 nM 4.41
CHEMBL4092474 EC50 = 48900.0 nM 4.31
CHEMBL31634 BRIVUDINE EC50 = 58800.0 nM 4.23
CHEMBL4064156 EC50 = 100000.0 nM 4.00
CHEMBL5314375 CIDOFOVIR EC50 - -
CHEMBL182 GANCICLOVIR EC50 - -
CHEMBL4085723 EC50 > 800.0 nM -
CHEMBL4090051 EC50 > 100000.0 nM -
CHEMBL4062012 EC50 > 100000.0 nM -
CHEMBL4100217 EC50 = 128000.0 nM -