Assay Detail
Functional
CHEMBL4046302
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Antitrypanosomal activity against Trypanosoma brucei Lister 427 bloodstream forms assessed as inhibition of parasite growth incubated for 48 hrs by ATP-bioluminescence cell viability assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of analogs of 5'-(((Z)-4-amino-2-butenyl)methylamino)-5'-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 6.45 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL512274 | — | — | 1 | 8.74 |
| CHEMBL381751 | — | — | 1 | 8.00 |
| CHEMBL4092771 | — | — | 1 | 6.80 |
| CHEMBL4100498 | — | — | 1 | 6.44 |
| CHEMBL4084041 | — | — | 1 | 6.43 |
| CHEMBL4094107 | — | — | 1 | 6.38 |
| CHEMBL4073680 | — | — | 1 | 5.60 |
| CHEMBL4087972 | — | — | 1 | 5.58 |
| CHEMBL4073465 | — | — | 1 | 5.52 |
| CHEMBL4062325 | — | — | 1 | 5.00 |
| CHEMBL4085520 | — | — | 1 | - |
| CHEMBL4103447 | — | — | 1 | - |
| CHEMBL4102756 | — | — | 1 | - |
| CHEMBL4078482 | — | — | 1 | - |
| CHEMBL4076008 | — | — | 1 | - |
| CHEMBL4086336 | — | — | 1 | - |
| CHEMBL4083844 | — | — | 1 | - |
| CHEMBL4080100 | — | — | 1 | - |
| CHEMBL4091618 | — | — | 1 | - |
| CHEMBL4063836 | — | — | 1 | - |
| CHEMBL4091805 | — | — | 1 | - |
| CHEMBL4065088 | — | — | 1 | - |
| CHEMBL4101847 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL512274 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL381751 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4092771 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4100498 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4084041 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4094107 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL4073680 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4087972 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4073465 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4062325 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4085520 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL4103447 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL4102756 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL4078482 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL4076008 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL4086336 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL4083844 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL4080100 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL4091618 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL4063836 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL4091805 | — | EC50 | > | 3000.0 | nM | - |
| CHEMBL4065088 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL4101847 | — | EC50 | > | 3000.0 | nM | - |