Assay Detail
Binding
CHEMBL4046326
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human OCT2 expressed in HEK293 cells assessed as decrease in uptake of substrate [3H]MPP+ after 1 min by liquid scintillation counting method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 22 member 2 (CHEMBL1743122) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A new chemotype inhibitor for the human organic cation transporter 3 (hOCT3).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.64 | 5.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4100146 | — | — | 1 | 5.36 |
| CHEMBL4062501 | — | — | 1 | 5.08 |
| CHEMBL43415 | — | — | 1 | 5.03 |
| CHEMBL1160763 | — | — | 1 | 4.95 |
| CHEMBL41040 | — | — | 1 | 4.72 |
| CHEMBL1160766 | — | — | 1 | 4.32 |
| CHEMBL13823 | — | — | 1 | 4.22 |
| CHEMBL14047 | PHENYLGUANIDINE | — | 1 | 4.05 |
| CHEMBL272259 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4100146 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4062501 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL43415 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL1160763 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL41040 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL1160766 | — | IC50 | = | 48300.0 | nM | 4.32 |
| CHEMBL13823 | — | IC50 | = | 60500.0 | nM | 4.22 |
| CHEMBL14047 | PHENYLGUANIDINE | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL272259 | — | IC50 | = | 96200.0 | nM | 4.02 |