Assay Detail
ADMET
CHEMBL4046491
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant CYP3A4 expressed in baculovirus-infected insect cells using 7-Benzoyloxy-4-trifluoromethyl coumarin substrate in presence of NADP+ by fluorescence based assay
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 5.15 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4102233 | — | — | 1 | 5.44 |
| CHEMBL4064295 | — | — | 1 | 5.31 |
| CHEMBL4084268 | — | — | 1 | 5.26 |
| CHEMBL4071736 | — | — | 1 | 5.20 |
| CHEMBL4061129 | — | — | 1 | 5.20 |
| CHEMBL4100176 | — | — | 1 | 4.86 |
| CHEMBL4074392 | — | — | 1 | 4.78 |
| CHEMBL4095822 | — | — | 1 | - |
| CHEMBL4097000 | — | — | 1 | - |
| CHEMBL4098747 | — | — | 1 | - |
| CHEMBL4071739 | — | — | 1 | - |
| CHEMBL4075332 | — | — | 1 | - |
| CHEMBL4082252 | — | — | 1 | - |
| CHEMBL4083744 | — | — | 1 | - |
| CHEMBL4104727 | — | — | 1 | - |
| CHEMBL4080500 | — | — | 1 | - |
| CHEMBL4071860 | — | — | 1 | - |
| CHEMBL4089301 | — | — | 1 | - |
| CHEMBL4068484 | — | — | 1 | - |
| CHEMBL4092435 | — | — | 1 | - |
| CHEMBL4064737 | — | — | 1 | - |
| CHEMBL4072883 | — | — | 1 | - |
| CHEMBL4094879 | — | — | 1 | - |
| CHEMBL4084685 | — | — | 1 | - |
| CHEMBL4102624 | — | — | 1 | - |
| CHEMBL4086750 | — | — | 1 | - |
| CHEMBL4065325 | — | — | 1 | - |
| CHEMBL4094490 | — | — | 1 | - |
| CHEMBL4073933 | — | — | 1 | - |
| CHEMBL4073324 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4102233 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL4064295 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4084268 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4071736 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4061129 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4100176 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL4074392 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL4100208 | — | IC50 | - | — | - | |
| CHEMBL4080500 | — | IC50 | - | — | - | |
| CHEMBL4073353 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4076229 | — | IC50 | - | — | - | |
| CHEMBL4101414 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4069801 | — | IC50 | - | — | - | |
| CHEMBL4097000 | — | IC50 | - | — | - | |
| CHEMBL4089301 | — | IC50 | - | — | - | |
| CHEMBL4071860 | — | IC50 | - | — | - | |
| CHEMBL4061793 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4092025 | — | IC50 | - | — | - | |
| CHEMBL4062009 | — | IC50 | - | — | - | |
| CHEMBL4102647 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4084713 | — | IC50 | - | — | - | |
| CHEMBL4064762 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4092463 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4087220 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4065798 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4099769 | — | IC50 | - | — | - | |
| CHEMBL4064737 | — | IC50 | - | — | - | |
| CHEMBL4073324 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4073933 | — | IC50 | - | — | - | |
| CHEMBL4094490 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4065325 | — | IC50 | - | — | - | |
| CHEMBL4086750 | — | IC50 | - | — | - | |
| CHEMBL4102624 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4084685 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4094879 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4072883 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4104727 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4092435 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4068484 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4095822 | — | IC50 | - | — | - | |
| CHEMBL4098747 | — | IC50 | - | — | - | |
| CHEMBL4071739 | — | IC50 | - | — | - | |
| CHEMBL4075332 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4082252 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL4083744 | — | IC50 | > | 20000.0 | nM | - |