Assay Detail
ADMET
CHEMBL4048100
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of equine serum BuChE incubated for 15 mins by Ellman's method
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.48 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.32 |
| CHEMBL4093622 | — | — | 1 | 4.50 |
| CHEMBL4069471 | — | — | 1 | 4.43 |
| CHEMBL4090497 | — | — | 1 | 4.34 |
| CHEMBL4099142 | — | — | 1 | 4.34 |
| CHEMBL4072178 | — | — | 1 | 4.33 |
| CHEMBL4065727 | — | — | 1 | 4.12 |
| CHEMBL4082669 | — | — | 1 | - |
| CHEMBL8706 | CLORGILINE | 2.0 | 1 | - |
| CHEMBL887 | RASAGILINE | 4.0 | 1 | - |
| CHEMBL92401 | IPRONIAZID | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 4760.0 | nM | 5.32 |
| CHEMBL4093622 | — | IC50 | = | 31400.0 | nM | 4.50 |
| CHEMBL4069471 | — | IC50 | = | 37200.0 | nM | 4.43 |
| CHEMBL4090497 | — | IC50 | = | 46100.0 | nM | 4.34 |
| CHEMBL4099142 | — | IC50 | = | 45700.0 | nM | 4.34 |
| CHEMBL4072178 | — | IC50 | = | 46500.0 | nM | 4.33 |
| CHEMBL4065727 | — | IC50 | = | 75400.0 | nM | 4.12 |
| CHEMBL4082669 | — | IC50 | = | 137000.0 | nM | - |
| CHEMBL8706 | CLORGILINE | IC50 | - | — | - | |
| CHEMBL887 | RASAGILINE | IC50 | - | — | - | |
| CHEMBL92401 | IPRONIAZID | IC50 | - | — | - |