Assay Detail
Binding
CHEMBL4048606
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]SYM2081 from recombinant homomeric rat GluK1 receptor expressed in baculovirus infected Sf9 insect cell membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glutamate receptor ionotropic, kainate 1 (CHEMBL2919) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
( S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements and Structural and Biological Investigation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.11 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL337577 | — | — | 1 | 7.36 |
| CHEMBL4075364 | — | — | 1 | 6.45 |
| CHEMBL4077177 | — | — | 1 | 6.23 |
| CHEMBL4066795 | — | — | 1 | 6.06 |
| CHEMBL4083716 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL337577 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL4075364 | — | Ki | = | 356.0 | nM | 6.45 |
| CHEMBL4077177 | — | Ki | = | 586.0 | nM | 6.23 |
| CHEMBL4066795 | — | Ki | = | 869.0 | nM | 6.06 |
| CHEMBL4083716 | — | Ki | = | 36000.0 | nM | 4.44 |