Assay Detail
Binding
CHEMBL4048893
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]NMS from human muscarinic M5 receptor expressed in CHO cell membranes after 2 hrs by liquid scintillation counting method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M5 (CHEMBL2035) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D4 Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.29 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4093527 | — | — | 1 | 6.12 |
| CHEMBL4098720 | — | — | 1 | 5.71 |
| CHEMBL4091231 | — | — | 1 | 5.69 |
| CHEMBL4080675 | — | — | 1 | 5.45 |
| CHEMBL4072818 | — | — | 1 | 5.43 |
| CHEMBL4091058 | — | — | 1 | 5.22 |
| CHEMBL4063176 | — | — | 1 | 5.10 |
| CHEMBL4064222 | — | — | 1 | 5.04 |
| CHEMBL4074104 | — | — | 1 | 4.62 |
| CHEMBL4085780 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4093527 | — | Ki | = | 758.58 | nM | 6.12 |
| CHEMBL4098720 | — | Ki | = | 1949.84 | nM | 5.71 |
| CHEMBL4091231 | — | Ki | = | 2041.74 | nM | 5.69 |
| CHEMBL4080675 | — | Ki | = | 3548.13 | nM | 5.45 |
| CHEMBL4072818 | — | Ki | = | 3715.35 | nM | 5.43 |
| CHEMBL4091058 | — | Ki | = | 6025.6 | nM | 5.22 |
| CHEMBL4063176 | — | Ki | = | 7943.28 | nM | 5.10 |
| CHEMBL4064222 | — | Ki | = | 9120.11 | nM | 5.04 |
| CHEMBL4074104 | — | Ki | = | 23988.33 | nM | 4.62 |
| CHEMBL4085780 | — | Ki | = | 27542.29 | nM | 4.56 |