Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4050600

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human DU145 cells assessed as reduction in metabolic activity after 72 hrs by MTT assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type DU-145
Confidence 1 — Organism
Curated By Autocuration

Target

DU-145 (CHEMBL613508)
Type CELL-LINE
Organism Homo sapiens

Publication

Positional Scanning Identifies the Molecular Determinants of a High Affinity Multi-Leucine Inhibitor for Furin and PACE4.
Małuch I, Levesque C, Kwiatkowska A, Couture F, Ly K, Desjardins R, Neugebauer WA, Prahl A, Day R.
J Med Chem (2017) 60 : 2732 -2744
PubMed 28287731 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 4.44 4.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4061737 1 4.92
CHEMBL4095698 1 4.70
CHEMBL4099504 1 4.64
CHEMBL4089351 1 4.64
CHEMBL4103458 1 4.60
CHEMBL4094278 1 4.57
CHEMBL4095200 1 4.52
CHEMBL4065627 1 4.51
CHEMBL4070834 1 4.50
CHEMBL4072868 1 4.46
CHEMBL4085516 1 4.44
CHEMBL4068349 1 4.43
CHEMBL4067486 1 4.42
CHEMBL4077533 1 4.40
CHEMBL4075692 1 4.35
CHEMBL4075606 1 4.30
CHEMBL4066673 1 4.30
CHEMBL4061196 1 4.12
CHEMBL4102947 1 4.05
CHEMBL4069865 1 4.00
CHEMBL4097058 1 -
CHEMBL4080551 1 -
CHEMBL4078666 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4061737 IC50 = 12000.0 nM 4.92
CHEMBL4095698 IC50 = 20000.0 nM 4.70
CHEMBL4099504 IC50 = 23000.0 nM 4.64
CHEMBL4089351 IC50 = 23000.0 nM 4.64
CHEMBL4103458 IC50 = 25000.0 nM 4.60
CHEMBL4094278 IC50 = 27000.0 nM 4.57
CHEMBL4095200 IC50 = 30000.0 nM 4.52
CHEMBL4065627 IC50 = 31000.0 nM 4.51
CHEMBL4070834 IC50 = 32000.0 nM 4.50
CHEMBL4072868 IC50 = 35000.0 nM 4.46
CHEMBL4085516 IC50 = 36000.0 nM 4.44
CHEMBL4068349 IC50 = 37000.0 nM 4.43
CHEMBL4067486 IC50 = 38000.0 nM 4.42
CHEMBL4077533 IC50 = 40000.0 nM 4.40
CHEMBL4075692 IC50 = 45000.0 nM 4.35
CHEMBL4075606 IC50 = 50000.0 nM 4.30
CHEMBL4066673 IC50 = 50000.0 nM 4.30
CHEMBL4061196 IC50 = 75000.0 nM 4.12
CHEMBL4102947 IC50 = 90000.0 nM 4.05
CHEMBL4069865 IC50 = 100000.0 nM 4.00
CHEMBL4097058 IC50 = 140000.0 nM -
CHEMBL4080551 IC50 = 150000.0 nM -
CHEMBL4078666 IC50 = 150000.0 nM -