Assay Detail
Binding
CHEMBL4050861
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3K p110delta/p85alpha (unknown origin) using lipid substrate after 40 mins by kinase-glo luminescence assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of novel 6-aryl substituted 4-anilinequinazoline derivatives as potential PI3Kδ inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.20 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 8.57 |
| CHEMBL4078784 | — | — | 1 | 8.03 |
| CHEMBL4087607 | — | — | 1 | 8.01 |
| CHEMBL4084606 | — | — | 1 | - |
| CHEMBL4077058 | — | — | 1 | - |
| CHEMBL4100426 | — | — | 1 | - |
| CHEMBL4082413 | — | — | 1 | - |
| CHEMBL4065202 | — | — | 1 | - |
| CHEMBL4086642 | — | — | 1 | - |
| CHEMBL4103062 | — | — | 1 | - |
| CHEMBL4095306 | — | — | 1 | - |
| CHEMBL4067897 | — | — | 1 | - |
| CHEMBL4105490 | — | — | 1 | - |
| CHEMBL4079732 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2216870 | IDELALISIB | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL4078784 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL4087607 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL4084606 | — | IC50 | - | — | - | |
| CHEMBL4077058 | — | IC50 | - | — | - | |
| CHEMBL4100426 | — | IC50 | - | — | - | |
| CHEMBL4082413 | — | IC50 | - | — | - | |
| CHEMBL4065202 | — | IC50 | - | — | - | |
| CHEMBL4086642 | — | IC50 | - | — | - | |
| CHEMBL4103062 | — | IC50 | - | — | - | |
| CHEMBL4095306 | — | IC50 | - | — | - | |
| CHEMBL4067897 | — | IC50 | - | — | - | |
| CHEMBL4105490 | — | IC50 | - | — | - | |
| CHEMBL4079732 | — | IC50 | - | — | - |