Assay Detail
Binding
CHEMBL4051809
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 17beta-HSD1 in human T47D cells preincubated for 1 hr followed by addition of [3H]-E1/E1 as substrate measured after 30 mins by HPLC based radio-detection method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
17-beta-hydroxysteroid dehydrogenase type 1 (CHEMBL3181) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
First Dual Inhibitors of Steroid Sulfatase (STS) and 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1): Designed Multiple Ligands as Novel Potential Therapeutics for Estrogen-Dependent Diseases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.61 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4071588 | — | — | 1 | 8.10 |
| CHEMBL4102153 | — | — | 1 | 7.70 |
| CHEMBL4071245 | — | — | 1 | 7.65 |
| CHEMBL4091943 | — | — | 1 | 7.38 |
| CHEMBL4064200 | — | — | 1 | 7.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4071588 | — | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL4102153 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4071245 | — | IC50 | = | 22.2 | nM | 7.65 |
| CHEMBL4091943 | — | IC50 | = | 42.1 | nM | 7.38 |
| CHEMBL4064200 | — | IC50 | = | 60.9 | nM | 7.21 |