Assay Detail
Functional
CHEMBL4056995
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Antiproliferative activity against human KG1 cells after 72 hrs by CCK-8 assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KG-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of 1H-indazol-3-amine derivatives as potent fibroblast growth factor receptor inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.00 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3348846 | FEXAGRATINIB | 2.0 | 1 | 8.48 |
| CHEMBL4105407 | — | — | 1 | 7.60 |
| CHEMBL4096740 | — | — | 1 | 7.38 |
| CHEMBL4078715 | — | — | 1 | 7.33 |
| CHEMBL4086560 | — | — | 1 | 7.29 |
| CHEMBL4076610 | — | — | 1 | 6.55 |
| CHEMBL4090974 | — | — | 1 | 6.48 |
| CHEMBL4081153 | — | — | 1 | 6.46 |
| CHEMBL4104460 | — | — | 1 | 6.22 |
| CHEMBL4079317 | — | — | 1 | 6.17 |
| CHEMBL4105046 | — | — | 1 | - |
| CHEMBL4087200 | — | — | 1 | - |
| CHEMBL4092994 | — | — | 1 | - |
| CHEMBL4072232 | — | — | 1 | - |
| CHEMBL4076490 | — | — | 1 | - |
| CHEMBL4099060 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3348846 | FEXAGRATINIB | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL4105407 | — | IC50 | = | 25.3 | nM | 7.60 |
| CHEMBL4096740 | — | IC50 | = | 41.5 | nM | 7.38 |
| CHEMBL4078715 | — | IC50 | = | 47.3 | nM | 7.33 |
| CHEMBL4086560 | — | IC50 | = | 51.5 | nM | 7.29 |
| CHEMBL4076610 | — | IC50 | = | 283.9 | nM | 6.55 |
| CHEMBL4090974 | — | IC50 | = | 332.6 | nM | 6.48 |
| CHEMBL4081153 | — | IC50 | = | 347.7 | nM | 6.46 |
| CHEMBL4104460 | — | IC50 | = | 595.4 | nM | 6.22 |
| CHEMBL4079317 | — | IC50 | = | 683.9 | nM | 6.17 |
| CHEMBL4105046 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4087200 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4092994 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4072232 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4076490 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4099060 | — | IC50 | > | 1000.0 | nM | - |