Compound Detail
CHEMBL4099060
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COCCN1CCN(c2ccc(C(=O)Nc3n[nH]c4cc(-c5c(F)cc(F)c(OC)c5F)ccc34)cc2)CC1
Basic Information
| ChEMBL ID | CHEMBL4099060 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JQDCEZKFIOQSIK-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
539.6
MW (Da)
4.68
ALogP
6
HBA
2
HBD
82.7
PSA (Ų)
0.34
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 7.04 | 7.04 | 91.0 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 7.0 | 7.0 | 99.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 2 | IC50 | = | 91.0 | nM | 7.04 | Inhibition of recombinant FGFR2 (unknown origin) using poly (Glu,Tyr)4:1 as subs... | 28687204 |
| Fibroblast growth factor receptor 1 | IC50 | = | 99.3 | nM | 7.0 | Inhibition of recombinant FGFR1 (unknown origin) using poly (Glu,Tyr)4:1 as subs... | 28687204 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28687204 | 10.1016/j.bmcl.2017.06.068 | Fibroblast growth factor receptor 1 | 1 |
| 28687204 | 10.1016/j.bmcl.2017.06.068 | Fibroblast growth factor receptor 2 | 1 |
| 28687204 | 10.1016/j.bmcl.2017.06.068 | KG-1 | 1 |
| 28687204 | 10.1016/j.bmcl.2017.06.068 | SNU-16 | 1 |
Data from ChEMBL 36 via Core Engine