Assay Detail
Binding
CHEMBL4056997
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Inhibition of recombinant FGFR1 (unknown origin) using poly (Glu,Tyr)4:1 as substrate after 60 mins by ELISA based spectrophotometric analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization of 1H-indazol-3-amine derivatives as potent fibroblast growth factor receptor inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.73 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3348846 | FEXAGRATINIB | 2.0 | 1 | 8.92 |
| CHEMBL4086560 | — | — | 1 | 8.43 |
| CHEMBL4096740 | — | — | 1 | 8.25 |
| CHEMBL4076610 | — | — | 1 | 8.21 |
| CHEMBL4078715 | — | — | 1 | 7.98 |
| CHEMBL4104460 | — | — | 1 | 7.89 |
| CHEMBL4081153 | — | — | 1 | 7.85 |
| CHEMBL4090974 | — | — | 1 | 7.68 |
| CHEMBL4079317 | — | — | 1 | 7.45 |
| CHEMBL4076490 | — | — | 1 | 7.31 |
| CHEMBL4099060 | — | — | 1 | 7.00 |
| CHEMBL4087200 | — | — | 1 | 6.83 |
| CHEMBL4105046 | — | — | 1 | 6.66 |
| CHEMBL4092994 | — | — | 1 | - |
| CHEMBL4072232 | — | — | 1 | - |
| CHEMBL4105407 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3348846 | FEXAGRATINIB | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4086560 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL4096740 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL4076610 | — | IC50 | = | 6.2 | nM | 8.21 |
| CHEMBL4078715 | — | IC50 | = | 10.4 | nM | 7.98 |
| CHEMBL4104460 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4081153 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4090974 | — | IC50 | = | 21.1 | nM | 7.68 |
| CHEMBL4079317 | — | IC50 | = | 35.2 | nM | 7.45 |
| CHEMBL4076490 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL4099060 | — | IC50 | = | 99.3 | nM | 7.00 |
| CHEMBL4087200 | — | IC50 | = | 147.6 | nM | 6.83 |
| CHEMBL4105046 | — | IC50 | = | 219.6 | nM | 6.66 |
| CHEMBL4092994 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4072232 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4105407 | — | IC50 | < | 4.1 | nM | - |