Assay Detail
Binding
CHEMBL4057958
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Inhibition of FGR (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 3-morpholino-imidazole[1,5-a]pyrazine BTK inhibitors for rheumatoid arthritis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.17 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4077588 | — | — | 1 | 7.66 |
| CHEMBL4076024 | — | — | 1 | 7.55 |
| CHEMBL4060757 | — | — | 1 | 7.41 |
| CHEMBL4062498 | — | — | 1 | 7.16 |
| CHEMBL4069387 | — | — | 1 | 6.69 |
| CHEMBL4075954 | — | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4077588 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4076024 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4060757 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4062498 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4069387 | — | IC50 | = | 203.0 | nM | 6.69 |
| CHEMBL4075954 | — | IC50 | = | 268.0 | nM | 6.57 |