Assay Detail
Binding
CHEMBL4058430
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of fluormone-AL Green from recombinant rat His-tagged/GST-fused androgen receptor LBD expressed in baculovirus expression system measured after 1.5 hrs by fluorescence polarization assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel 3-oxo-4-oxa-5α-androst-17β-amide derivatives as dual 5α-reductase inhibitors and androgen receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.61 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4076351 | — | — | 1 | 4.77 |
| CHEMBL258918 | MESTEROLONE | 2.0 | 1 | 4.74 |
| CHEMBL4061869 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4076351 | — | IC50 | = | 16840.0 | nM | 4.77 |
| CHEMBL258918 | MESTEROLONE | IC50 | = | 18280.0 | nM | 4.74 |
| CHEMBL4061869 | — | IC50 | = | 47610.0 | nM | 4.32 |