Assay Detail
Binding
CHEMBL4119544
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Displacement of [3H]NMS from recombinant human muscarinic M1 receptor expressed in CHOK1 cell membranes after 120 mins by scintillation counting method
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.16 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2078942 | — | — | 1 | 8.90 |
| CHEMBL4128341 | — | — | 1 | 8.34 |
| CHEMBL4129580 | — | — | 1 | 8.05 |
| CHEMBL2078987 | — | — | 1 | 7.45 |
| CHEMBL4126071 | — | — | 1 | 7.38 |
| CHEMBL1734 | SOLIFENACIN | 4.0 | 1 | 7.29 |
| CHEMBL4126290 | — | — | 1 | 7.26 |
| CHEMBL4127373 | — | — | 1 | 7.17 |
| CHEMBL4127428 | — | — | 1 | 6.92 |
| CHEMBL4129723 | — | — | 1 | 6.79 |
| CHEMBL4130037 | — | — | 1 | 6.72 |
| CHEMBL4128497 | — | — | 1 | 6.71 |
| CHEMBL4128667 | — | — | 1 | 6.42 |
| CHEMBL4128764 | — | — | 1 | 6.18 |
| CHEMBL4129382 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2078942 | — | Ki | = | 1.259 | nM | 8.90 |
| CHEMBL4128341 | — | Ki | = | 4.571 | nM | 8.34 |
| CHEMBL4129580 | — | Ki | = | 8.913 | nM | 8.05 |
| CHEMBL2078987 | — | Ki | = | 35.48 | nM | 7.45 |
| CHEMBL4126071 | — | Ki | = | 41.69 | nM | 7.38 |
| CHEMBL1734 | SOLIFENACIN | Ki | = | 51.29 | nM | 7.29 |
| CHEMBL4126290 | — | Ki | = | 54.95 | nM | 7.26 |
| CHEMBL4127373 | — | Ki | = | 67.61 | nM | 7.17 |
| CHEMBL4127428 | — | Ki | = | 120.23 | nM | 6.92 |
| CHEMBL4129723 | — | Ki | = | 162.18 | nM | 6.79 |
| CHEMBL4130037 | — | Ki | = | 190.55 | nM | 6.72 |
| CHEMBL4128497 | — | Ki | = | 194.98 | nM | 6.71 |
| CHEMBL4128667 | — | Ki | = | 380.19 | nM | 6.42 |
| CHEMBL4128764 | — | Ki | = | 660.69 | nM | 6.18 |
| CHEMBL4129382 | — | Ki | = | 1698.24 | nM | 5.77 |