Assay Detail
Functional
CHEMBL4121249
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human mammary gland oxytocin receptor expressed in CHO cells assessed as inhibition of agonist-induced intracellular calcium flux preincubated for 20 mins followed by oxytocin addition measured for 5 mins by Fluo-4-AM dye based FLIPR assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Building bridges for highly selective, potent and stable oxytocin and vasopressin analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.76 | 5.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4126100 | — | — | 1 | 5.76 |
| CHEMBL4129142 | — | — | 1 | - |
| CHEMBL4128839 | — | — | 1 | - |
| CHEMBL4127791 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4126100 | — | IC50 | = | 1724.0 | nM | 5.76 |
| CHEMBL4129142 | — | IC50 | - | — | - | |
| CHEMBL4128839 | — | IC50 | - | — | - | |
| CHEMBL4127791 | — | IC50 | - | — | - |