Assay Detail
Binding
CHEMBL4122691
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of SERT (unknown origin) expressed in HEK293 cells assessed as reduction in 5-HT uptake incubated for 30 mins
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.68 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439849 | VILAZODONE | 4.0 | 1 | 9.40 |
| CHEMBL549 | CITALOPRAM | 4.0 | 1 | 8.20 |
| CHEMBL4126644 | — | — | 1 | 7.69 |
| CHEMBL4128689 | — | — | 1 | 7.66 |
| CHEMBL4126958 | — | — | 1 | 6.64 |
| CHEMBL4129019 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439849 | VILAZODONE | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL549 | CITALOPRAM | IC50 | = | 6.27 | nM | 8.20 |
| CHEMBL4126644 | — | IC50 | = | 20.42 | nM | 7.69 |
| CHEMBL4128689 | — | IC50 | = | 22.1 | nM | 7.66 |
| CHEMBL4126958 | — | IC50 | = | 229.3 | nM | 6.64 |
| CHEMBL4129019 | — | IC50 | = | 314.1 | nM | 6.50 |