Assay Detail
Functional
CHEMBL4123800
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Antiproliferative activity against docetaxel-sensitive human DU145 cells after 3 days by WST-1 assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Optimized synthesis and antiproliferative activity of desTHPdactylolides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.74 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92 | DOCETAXEL ANHYDROUS | 4.0 | 1 | 8.92 |
| CHEMBL4129744 | — | — | 1 | 5.50 |
| CHEMBL4128735 | — | — | 1 | 5.27 |
| CHEMBL4129422 | — | — | 1 | 5.04 |
| CHEMBL4129818 | — | — | 1 | 4.94 |
| CHEMBL4128045 | — | — | 1 | 4.75 |
| CHEMBL4126462 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92 | DOCETAXEL ANHYDROUS | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4129744 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL4128735 | — | IC50 | = | 5410.0 | nM | 5.27 |
| CHEMBL4129422 | — | IC50 | = | 9210.0 | nM | 5.04 |
| CHEMBL4129818 | — | IC50 | = | 11580.0 | nM | 4.94 |
| CHEMBL4128045 | — | IC50 | = | 17760.0 | nM | 4.75 |
| CHEMBL4126462 | — | IC50 | > | 30000.0 | nM | - |