Assay Detail
ADMET
CHEMBL4124011
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Inhibition of human CYP3A4 using testosterone as substrate by LC-MS/MS analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of functionalized piperazin-1yl-(E)-stilbenes as inhibitors of 17α-hydroxylase-C17,20-lyase (Cyp17).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.16 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 6.84 |
| CHEMBL4126284 | — | — | 1 | 6.61 |
| CHEMBL4129721 | — | — | 1 | 6.16 |
| CHEMBL4128368 | — | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL4126284 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL4129721 | — | IC50 | = | 695.0 | nM | 6.16 |
| CHEMBL4128368 | — | IC50 | = | 9360.0 | nM | 5.03 |