Assay Detail
Binding
CHEMBL4124626
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Inhibition of PIM1 (unknown origin)
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 7.44 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4129087 | — | — | 1 | 8.52 |
| CHEMBL4125914 | — | — | 1 | 8.52 |
| CHEMBL3264257 | — | — | 1 | 8.52 |
| CHEMBL4126750 | — | — | 1 | 8.30 |
| CHEMBL4125725 | — | — | 1 | 8.30 |
| CHEMBL1952329 | SGI-1776 | 1.0 | 1 | 8.15 |
| CHEMBL4129929 | — | — | 1 | 8.15 |
| CHEMBL4126848 | — | — | 1 | 8.15 |
| CHEMBL4128290 | — | — | 1 | 8.15 |
| CHEMBL4130104 | — | — | 1 | 8.10 |
| CHEMBL4129779 | — | — | 1 | 8.05 |
| CHEMBL4128288 | — | — | 1 | 8.05 |
| CHEMBL4128205 | — | — | 1 | 8.05 |
| CHEMBL4127644 | — | — | 1 | 8.05 |
| CHEMBL4126656 | — | — | 1 | 7.92 |
| CHEMBL4130169 | — | — | 1 | 7.72 |
| CHEMBL4125999 | — | — | 1 | 7.72 |
| CHEMBL4129118 | — | — | 1 | 7.68 |
| CHEMBL4130257 | — | — | 1 | 7.68 |
| CHEMBL4128740 | — | — | 1 | 7.68 |
| CHEMBL4129891 | — | — | 1 | 7.66 |
| CHEMBL4130159 | — | — | 1 | 7.64 |
| CHEMBL4129023 | — | — | 1 | 7.52 |
| CHEMBL4126689 | — | — | 1 | 7.48 |
| CHEMBL4126847 | — | — | 1 | 7.46 |
| CHEMBL4126252 | — | — | 1 | 7.17 |
| CHEMBL4129352 | — | — | 1 | 7.02 |
| CHEMBL4128901 | — | — | 1 | 6.87 |
| CHEMBL4126778 | — | — | 1 | 6.84 |
| CHEMBL4130297 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4129087 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3264257 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4125914 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4126750 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4125725 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1952329 | SGI-1776 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4129929 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4126848 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4128290 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4130104 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4128205 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4127644 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4128288 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4129779 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4126656 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4130169 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4125999 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4129118 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4130257 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4128740 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4129891 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4130159 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4129023 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4126689 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4126847 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4126252 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4129352 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL4128901 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL4126778 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL4130297 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4130071 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL4128705 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL4130160 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL4127890 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL4126344 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL4129044 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4126838 | — | IC50 | = | 307.0 | nM | 6.51 |
| CHEMBL4127463 | — | IC50 | = | 313.0 | nM | 6.50 |
| CHEMBL4129166 | — | IC50 | = | 443.0 | nM | 6.35 |
| CHEMBL4126500 | — | IC50 | = | 885.0 | nM | 6.05 |
| CHEMBL44541 | MERIDIANIN C | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4128811 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4127024 | — | IC50 | > | 10000.0 | nM | - |