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Compound Detail

CHEMBL4129044

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FC(F)(F)c1ccc(-c2c[nH]c3ccc(-c4cncc(N5CCNCC5)n4)cc23)cc1

Basic Information

ChEMBL ID CHEMBL4129044
Phase Preclinical
Structure Type MOL
InChI Key JNOYDDQBVMUSBF-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

423.4
MW (Da)
4.72
ALogP
4
HBA
2
HBD
56.8
PSA (Ų)
0.50
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H20F3N5
MW 423.44
Aromatic Rings 4
Heavy Atoms 31
NP-Likeness -1.02

Activity Summary

IC50 3 meas. best 6.62

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Serine/threonine-protein kinase pim-3
CHEMBL5407
IC50 6.62 6.62 241.0 1
Serine/threonine-protein kinase pim-1
CHEMBL2147
IC50 6.58 6.58 260.0 1
Serine/threonine-protein kinase pim-2
CHEMBL4523
IC50 5.67 5.67 2120.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
29871845 10.1016/j.bmcl.2018.05.054 Serine/threonine-protein kinase pim-1 1
29871845 10.1016/j.bmcl.2018.05.054 Serine/threonine-protein kinase pim-2 1
29871845 10.1016/j.bmcl.2018.05.054 Serine/threonine-protein kinase pim-3 1

Data from ChEMBL 36 via Core Engine