Assay Detail
Binding
CHEMBL4124627
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Inhibition of PIM2 (unknown origin)
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-2 (CHEMBL4523) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 5.98 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3264257 | — | — | 1 | 6.96 |
| CHEMBL4125914 | — | — | 1 | 6.66 |
| CHEMBL4125725 | — | — | 1 | 6.64 |
| CHEMBL4126750 | — | — | 1 | 6.59 |
| CHEMBL4129087 | — | — | 1 | 6.57 |
| CHEMBL1952329 | SGI-1776 | 1.0 | 1 | 6.44 |
| CHEMBL4126848 | — | — | 1 | 6.43 |
| CHEMBL4130104 | — | — | 1 | 6.34 |
| CHEMBL4126656 | — | — | 1 | 6.27 |
| CHEMBL4128290 | — | — | 1 | 6.25 |
| CHEMBL4128205 | — | — | 1 | 6.19 |
| CHEMBL4129023 | — | — | 1 | 6.19 |
| CHEMBL4127644 | — | — | 1 | 6.16 |
| CHEMBL4128740 | — | — | 1 | 6.11 |
| CHEMBL4125999 | — | — | 1 | 6.09 |
| CHEMBL4130257 | — | — | 1 | 6.08 |
| CHEMBL4128288 | — | — | 1 | 6.08 |
| CHEMBL4129779 | — | — | 1 | 6.06 |
| CHEMBL4129929 | — | — | 1 | 5.86 |
| CHEMBL4130159 | — | — | 1 | 5.85 |
| CHEMBL4129891 | — | — | 1 | 5.79 |
| CHEMBL4130169 | — | — | 1 | 5.75 |
| CHEMBL4129118 | — | — | 1 | 5.67 |
| CHEMBL4129044 | — | — | 1 | 5.67 |
| CHEMBL4126847 | — | — | 1 | 5.65 |
| CHEMBL4126689 | — | — | 1 | 5.59 |
| CHEMBL4128901 | — | — | 1 | 5.56 |
| CHEMBL4126778 | — | — | 1 | 5.37 |
| CHEMBL4130071 | — | — | 1 | 5.36 |
| CHEMBL4129352 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3264257 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4125914 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4125725 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4126750 | — | IC50 | = | 259.0 | nM | 6.59 |
| CHEMBL4129087 | — | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL1952329 | SGI-1776 | IC50 | = | 363.0 | nM | 6.44 |
| CHEMBL4126848 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4130104 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4126656 | — | IC50 | = | 537.0 | nM | 6.27 |
| CHEMBL4128290 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL4128205 | — | IC50 | = | 645.0 | nM | 6.19 |
| CHEMBL4129023 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4127644 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4128740 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL4125999 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4130257 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4128288 | — | IC50 | = | 841.0 | nM | 6.08 |
| CHEMBL4129779 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4129929 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL4130159 | — | IC50 | = | 1426.0 | nM | 5.85 |
| CHEMBL4129891 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL4130169 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4129044 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL4129118 | — | IC50 | = | 2160.0 | nM | 5.67 |
| CHEMBL4126847 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL4126689 | — | IC50 | = | 2540.0 | nM | 5.59 |
| CHEMBL4128901 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL4126778 | — | IC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL4130071 | — | IC50 | = | 4350.0 | nM | 5.36 |
| CHEMBL4129352 | — | IC50 | = | 4440.0 | nM | 5.35 |
| CHEMBL4130297 | — | IC50 | = | 5330.0 | nM | 5.27 |
| CHEMBL4126252 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4126344 | — | IC50 | = | 7950.0 | nM | 5.10 |
| CHEMBL4127024 | — | IC50 | - | — | - | |
| CHEMBL4128811 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL44541 | MERIDIANIN C | IC50 | - | — | - | |
| CHEMBL4126500 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4127890 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4127463 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4130160 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4128705 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4126838 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4129166 | — | IC50 | > | 10000.0 | nM | - |