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Compound Detail

CHEMBL4129352

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CN(C)CCNc1cncc(-c2ccc3[nH]cc(-c4ccc(OC(F)(F)F)cc4)c3c2)n1

Basic Information

ChEMBL ID CHEMBL4129352
Phase Preclinical
Structure Type MOL
InChI Key YRFCIKZEDHJVDM-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

441.5
MW (Da)
5.16
ALogP
5
HBA
2
HBD
66.1
PSA (Ų)
0.41
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H22F3N5O
MW 441.46
Aromatic Rings 4
Heavy Atoms 32
NP-Likeness -1.02

Activity Summary

IC50 3 meas. best 7.02

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Serine/threonine-protein kinase pim-1
CHEMBL2147
IC50 7.02 7.02 96.0 1
Serine/threonine-protein kinase pim-3
CHEMBL5407
IC50 6.63 6.63 236.0 1
Serine/threonine-protein kinase pim-2
CHEMBL4523
IC50 5.35 5.35 4440.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
29871845 10.1016/j.bmcl.2018.05.054 Serine/threonine-protein kinase pim-1 1
29871845 10.1016/j.bmcl.2018.05.054 Serine/threonine-protein kinase pim-2 1
29871845 10.1016/j.bmcl.2018.05.054 Serine/threonine-protein kinase pim-3 1

Data from ChEMBL 36 via Core Engine