Assay Detail
Functional
CHEMBL4124862
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Antiviral activity against thymidine kinase deficient Varicella-Zoster virus infected in HEL cells assessed as reduction in virus plaque formation
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 3 |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 18 | 4.46 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 6.24 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 4.83 |
| CHEMBL4126524 | — | — | 1 | 4.38 |
| CHEMBL4127182 | — | — | 1 | 4.33 |
| CHEMBL4128419 | — | — | 1 | 4.33 |
| CHEMBL4129158 | — | — | 1 | 4.28 |
| CHEMBL4129784 | — | — | 1 | 4.27 |
| CHEMBL4126212 | — | — | 1 | 4.26 |
| CHEMBL4129391 | — | — | 1 | 4.23 |
| CHEMBL4129955 | — | — | 1 | 4.19 |
| CHEMBL4127759 | — | — | 1 | 4.15 |
| CHEMBL4126683 | — | — | 1 | 4.00 |
| CHEMBL4128997 | — | — | 1 | - |
| CHEMBL4125717 | — | — | 1 | - |
| CHEMBL4126084 | — | — | 1 | - |
| CHEMBL4127918 | — | — | 1 | - |
| CHEMBL4128569 | — | — | 1 | - |
| CHEMBL4127582 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 14870.0 | nM | 4.83 |
| CHEMBL4126524 | — | EC50 | = | 41570.0 | nM | 4.38 |
| CHEMBL4127182 | — | EC50 | = | 46660.0 | nM | 4.33 |
| CHEMBL4128419 | — | EC50 | = | 47190.0 | nM | 4.33 |
| CHEMBL4129158 | — | EC50 | = | 52530.0 | nM | 4.28 |
| CHEMBL4129784 | — | EC50 | = | 53480.0 | nM | 4.27 |
| CHEMBL4126212 | — | EC50 | = | 55270.0 | nM | 4.26 |
| CHEMBL4129391 | — | EC50 | = | 58480.0 | nM | 4.23 |
| CHEMBL4129955 | — | EC50 | = | 65100.0 | nM | 4.19 |
| CHEMBL4127759 | — | EC50 | = | 71520.0 | nM | 4.15 |
| CHEMBL4126683 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL4128997 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4125717 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4126084 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4127918 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4128569 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4127582 | — | EC50 | > | 100000.0 | nM | - |