Assay Detail
Binding
CHEMBL4131851
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]-Tyr0-sauvagine from human CRFR1 expressed in HEK293 cell membrane homogenates after 120 mins by gamma counting method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL1800) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of 2-imino and 2-hydrazono thiazolo[4,5-d]pyrimidines as corticotropin releasing factor (CRF) antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.73 | 7.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296641 | ANTALARMIN | — | 1 | 7.73 |
| CHEMBL4160471 | — | — | 1 | 6.77 |
| CHEMBL4161963 | — | — | 1 | 6.35 |
| CHEMBL4170184 | — | — | 1 | 6.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296641 | ANTALARMIN | IC50 | = | 18.62 | nM | 7.73 |
| CHEMBL4160471 | — | IC50 | = | 169.82 | nM | 6.77 |
| CHEMBL4161963 | — | IC50 | = | 446.68 | nM | 6.35 |
| CHEMBL4170184 | — | IC50 | = | 891.25 | nM | 6.05 |