Compound Detail
CHEMBL4161963
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Basic Information
| ChEMBL ID | CHEMBL4161963 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZYAABOHJYBVDCO-FCDQGJHFSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
370.5
MW (Da)
3.34
ALogP
7
HBA
1
HBD
72.3
PSA (Ų)
0.56
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.35
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 CHEMBL1800 | IC50 | 6.35 | 6.35 | 446.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 | IC50 | = | 446.68 | nM | 6.35 | Displacement of [125I]-Tyr0-sauvagine from human CRFR1 expressed in HEK293 cell ... | 28750312 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28750312 | 10.1016/j.ejmech.2017.07.016 | Corticotropin-releasing factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine