Assay Detail
Binding
CHEMBL4132668
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Inhibition of Wistar rat plasma angiotensin 1-converting enzyme using H-hippuryl-His-Leu-OH as substrate after 20 mins by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-function studies of BPP-BrachyNH2 and synthetic analogues thereof with Angiotensin I-Converting Enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.17 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1560 | CAPTOPRIL | 4.0 | 1 | 8.49 |
| CHEMBL4167962 | — | — | 1 | 5.26 |
| CHEMBL4163400 | — | — | 1 | 4.76 |
| CHEMBL4171298 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 3.23 | nM | 8.49 |
| CHEMBL4167962 | — | IC50 | = | 5510.0 | nM | 5.26 |
| CHEMBL4163400 | — | IC50 | = | 17480.0 | nM | 4.76 |
| CHEMBL4171298 | — | IC50 | = | 162400.0 | nM | - |