Assay Detail
Functional
CHEMBL4136776
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Antiproliferative activity against human HL60 cells after 62 hrs by MTS assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Sodium-Periodate-Mediated Harringtonine Derivatives and Their Antiproliferative Activity against HL-60 Acute Leukemia Cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.40 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46286 | OMACETAXINE MEPESUCCINATE | 4.0 | 1 | 7.66 |
| CHEMBL433257 | HARRINGTONINE | — | 1 | 7.33 |
| CHEMBL276462 | CEPHALOTAXINE | — | 1 | 4.21 |
| CHEMBL4169933 | — | — | 1 | - |
| CHEMBL4174131 | — | — | 1 | - |
| CHEMBL4166217 | — | — | 1 | - |
| CHEMBL4163866 | — | — | 1 | - |
| CHEMBL4174530 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46286 | OMACETAXINE MEPESUCCINATE | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL433257 | HARRINGTONINE | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL276462 | CEPHALOTAXINE | IC50 | = | 61200.0 | nM | 4.21 |
| CHEMBL4169933 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4174131 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4166217 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4163866 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4174530 | — | IC50 | > | 100000.0 | nM | - |