Compound Detail
CHEMBL276462
CEPHALOTAXINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL276462 |
| Name | CEPHALOTAXINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YMNCVRSYJBNGLD-KURKYZTESA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
315.4
MW (Da)
1.79
ALogP
5
HBA
1
HBD
51.2
PSA (Ų)
0.86
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MAP kinase p38 CHEMBL2094115 | IC50 | 6.7 | 6.7 | 200.0 | 1 |
| HL-60 CHEMBL383 | IC50 | 4.21 | 4.21 | 61200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MAP kinase p38 | IC50 | = | 200.0 | nM | 6.7 | Inhibition of anisomycin-induced p38 phosphorylation in human U937 cells by Phos... | 18157122 |
| HL-60 | IC50 | = | 61200.0 | nM | 4.21 | Antiproliferative activity against human HL60 cells after 62 hrs by MTS assay | 29286665 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18157122 | 10.1038/nchembio.2007.59 | MAP kinase p38 | 2 |
| 18157122 | 10.1038/nchembio.2007.59 | Janus Kinase (JAK) | 2 |
| 7707309 | 10.1021/jm00007a003 | Unchecked | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B1 | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B3 | 1 |
| 29286665 | 10.1021/acs.jnatprod.7b00541 | HL-60 | 1 |
| 36242991 | 10.1016/j.ejmech.2022.114731 | K562 | 1 |
| 36242991 | 10.1016/j.ejmech.2022.114731 | HL-60 | 1 |
| 36242991 | 10.1016/j.ejmech.2022.114731 | U-937 | 1 |
Data from ChEMBL 36 via Core Engine