Assay Detail
Functional
CHEMBL4137385
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Antiproliferative activity against human Jurkat T cells assessed as DNA content after 72 hrs by Hoechst 33258 dye-based fluorescence assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Targeting Myeloid Differentiation Using Potent 2-Hydroxypyrazolo[1,5- a]pyridine Scaffold-Based Human Dihydroorotate Dehydrogenase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.36 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4173846 | — | — | 1 | 6.12 |
| CHEMBL4165923 | — | — | 1 | 6.09 |
| CHEMBL38434 | BREQUINAR | 2.0 | 1 | 6.04 |
| CHEMBL4165815 | — | — | 1 | 5.83 |
| CHEMBL4177202 | — | — | 1 | 5.81 |
| CHEMBL4062046 | — | — | 1 | 5.73 |
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 1 | 4.36 |
| CHEMBL4167855 | — | — | 1 | 4.17 |
| CHEMBL4175712 | — | — | 1 | 4.05 |
| CHEMBL4169359 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4173846 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL4165923 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL38434 | BREQUINAR | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL4165815 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL4177202 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL4062046 | — | IC50 | = | 1880.0 | nM | 5.73 |
| CHEMBL973 | TERIFLUNOMIDE | IC50 | = | 43220.0 | nM | 4.36 |
| CHEMBL4167855 | — | IC50 | = | 67550.0 | nM | 4.17 |
| CHEMBL4175712 | — | IC50 | = | 89660.0 | nM | 4.05 |
| CHEMBL4169359 | — | IC50 | - | — | - |