Assay Detail
Binding
CHEMBL4138798
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FAAH in rat brain microsomes assessed as reduction in enzyme-mediated 4-pyren-1-ylbutanoic acid release using N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide as substrate incubated fro 60 mins by reversed phase HPLC method
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
(Indolylalkyl)piperidine carbamates as inhibitors of fatty acid amide hydrolase (FAAH).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.52 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4176744 | — | — | 1 | 7.34 |
| CHEMBL4162665 | — | — | 1 | 7.28 |
| CHEMBL184238 | URB-597 | 1.0 | 1 | 7.22 |
| CHEMBL3585525 | — | — | 1 | 7.05 |
| CHEMBL3585524 | — | — | 1 | 7.03 |
| CHEMBL4163613 | — | — | 1 | 6.96 |
| CHEMBL4166118 | — | — | 1 | 6.96 |
| CHEMBL4170471 | — | — | 1 | 6.89 |
| CHEMBL4167061 | — | — | 1 | 6.75 |
| CHEMBL4159300 | — | — | 1 | 6.75 |
| CHEMBL4167359 | — | — | 1 | 6.70 |
| CHEMBL3585526 | — | — | 1 | 6.62 |
| CHEMBL3585519 | — | — | 1 | 6.60 |
| CHEMBL4166514 | — | — | 1 | 6.51 |
| CHEMBL4169537 | — | — | 1 | 6.44 |
| CHEMBL4165979 | — | — | 1 | 6.39 |
| CHEMBL4173379 | — | — | 1 | 6.39 |
| CHEMBL4159152 | — | — | 1 | 6.24 |
| CHEMBL4173907 | — | — | 1 | 6.16 |
| CHEMBL4174430 | — | — | 1 | 6.10 |
| CHEMBL3585523 | — | — | 1 | 6.02 |
| CHEMBL4161620 | — | — | 1 | 6.01 |
| CHEMBL4175232 | — | — | 1 | 5.80 |
| CHEMBL4169941 | — | — | 1 | 5.77 |
| CHEMBL4174293 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4176744 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4162665 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL184238 | URB-597 | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3585525 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3585524 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL4163613 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4166118 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4170471 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4167061 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4159300 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4167359 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3585526 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3585519 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4166514 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4169537 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4165979 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4173379 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4159152 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4173907 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4174430 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL3585523 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4161620 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL4175232 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4169941 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4174293 | — | IC50 | = | 9800.0 | nM | 5.01 |