Assay Detail
Functional
CHEMBL4139224
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Antiproliferative activity against human DU145 cells after 120 hrs by MTT assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | DU-145 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Quinazoline based α1-adrenoreceptor antagonists with potent antiproliferative activity in human prostate cancer cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.66 | 4.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4171491 | — | — | 1 | 4.75 |
| CHEMBL4163587 | — | — | 1 | 4.73 |
| CHEMBL707 | DOXAZOSIN | 4.0 | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4171491 | — | IC50 | = | 17820.0 | nM | 4.75 |
| CHEMBL4163587 | — | IC50 | = | 18540.0 | nM | 4.73 |
| CHEMBL707 | DOXAZOSIN | IC50 | = | 30560.0 | nM | 4.51 |