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Assay Detail

CHEMBL4140551

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antitrypanosomal activity against Trypanosoma cruzi Y trypomastigotes infected in mouse J774 cells measured after 30 days by contrast phase microscopic method
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Trypanosoma cruzi
Cell Type J774
Confidence 1 — Organism
Curated By Intermediate

Target

Trypanosoma cruzi (CHEMBL368)
Type ORGANISM
Organism Trypanosoma cruzi

Publication

Structural design, synthesis and pharmacological evaluation of thiazoles against Trypanosoma cruzi.
de Oliveira Filho GB, Cardoso MVO, Espíndola JWP, Oliveira E Silva DA, Ferreira RS, Coelho PL, Anjos PSD, Santos ES, Meira CS, Moreira DRM, Soares MBP, Leite ACL.
Eur J Med Chem (2017) 141 : 346 -361
PubMed 29031078 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.15 5.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL90512 1 5.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL90512 IC50 = 7100.0 nM 5.15