Assay Detail
Functional
CHEMBL4140738
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Antiparasitic activity against Trypanosoma cruzi infected in mouse 3T3 cells assessed as growth inhibition after 96 hrs by beta-galactosidase reporter gene assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma cruzi |
| Cell Type | 3T3 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Optimization of physicochemical properties for 4-anilinoquinazoline inhibitors of trypanosome proliferation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 36 | 5.12 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4168740 | — | — | 1 | 7.22 |
| CHEMBL4171319 | — | — | 1 | 6.43 |
| CHEMBL4165142 | — | — | 1 | 5.66 |
| CHEMBL4177159 | — | — | 1 | 5.57 |
| CHEMBL4177008 | — | — | 1 | 5.47 |
| CHEMBL4171096 | — | — | 1 | 5.32 |
| CHEMBL4162775 | — | — | 1 | 5.29 |
| CHEMBL4176605 | — | — | 1 | 5.19 |
| CHEMBL3637894 | — | — | 1 | 5.16 |
| CHEMBL4164550 | — | — | 1 | 5.12 |
| CHEMBL4164489 | — | — | 1 | 5.05 |
| CHEMBL4175127 | — | — | 1 | 4.97 |
| CHEMBL4166222 | — | — | 1 | 4.96 |
| CHEMBL4167924 | — | — | 1 | 4.86 |
| CHEMBL4173481 | — | — | 1 | 4.86 |
| CHEMBL4173041 | — | — | 1 | 4.83 |
| CHEMBL4171216 | — | — | 1 | 4.82 |
| CHEMBL4173238 | — | — | 1 | 4.65 |
| CHEMBL4176462 | — | — | 1 | 4.62 |
| CHEMBL4175838 | — | — | 1 | 4.61 |
| CHEMBL4160007 | — | — | 1 | 4.57 |
| CHEMBL4159864 | — | — | 1 | 4.57 |
| CHEMBL4166390 | — | — | 1 | 4.50 |
| CHEMBL4169813 | — | — | 1 | 4.49 |
| CHEMBL4171831 | — | — | 1 | - |
| CHEMBL4176839 | — | — | 1 | - |
| CHEMBL4171268 | — | — | 1 | - |
| CHEMBL4161711 | — | — | 1 | - |
| CHEMBL4169642 | — | — | 1 | - |
| CHEMBL4163364 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4168740 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4171319 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4165142 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4177159 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4177008 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4171096 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4162775 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4176605 | — | EC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL3637894 | — | EC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL4164550 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4164489 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4175127 | — | EC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL4166222 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4167924 | — | EC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL4173481 | — | EC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL4173041 | — | EC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL4171216 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4173238 | — | EC50 | = | 22500.0 | nM | 4.65 |
| CHEMBL4176462 | — | EC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL4175838 | — | EC50 | = | 24400.0 | nM | 4.61 |
| CHEMBL4160007 | — | EC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL4159864 | — | EC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL4166390 | — | EC50 | = | 31500.0 | nM | 4.50 |
| CHEMBL4169813 | — | EC50 | = | 32200.0 | nM | 4.49 |
| CHEMBL4163176 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL4172435 | — | EC50 | > | 15000.0 | nM | - |
| CHEMBL4160939 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4160723 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4171684 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4161076 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4163364 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4169642 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4161711 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4171268 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4176839 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4171831 | — | EC50 | > | 20000.0 | nM | - |