Assay Detail
Binding
CHEMBL4142291
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Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis
10
Total Activities
9
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Oxyprenylated Phenylpropanoids Bind to MT1 Melatonin Receptors and Inhibit Breast Cancer Cell Proliferation and Migration.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.21 | 9.52 |
| KiL | 1 | - | - |
| KiH | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL45 | MELATONIN | 4.0 | 1 | 9.52 |
| CHEMBL4175759 | — | — | 1 | 6.43 |
| CHEMBL145781 | 7-BENZYLOXYCOUMARIN | — | 1 | 6.35 |
| CHEMBL2022666 | BOROPINAL | — | 1 | 6.11 |
| CHEMBL2268532 | 7-(2-PENTYNYLOXY)COUMARIN | — | 1 | 6.05 |
| CHEMBL307341 | AURAPTENE | — | 1 | 5.72 |
| CHEMBL156692 | 7-PRENYLOXYCOUMARIN | — | 1 | 5.28 |
| CHEMBL221960 | — | — | 1 | 4.23 |
| CHEMBL156127 | UMBELLIPRENIN | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL45 | MELATONIN | Ki | = | 0.3037 | nM | 9.52 |
| CHEMBL4175759 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL145781 | 7-BENZYLOXYCOUMARIN | Ki | = | 445.0 | nM | 6.35 |
| CHEMBL2022666 | BOROPINAL | Ki | = | 786.0 | nM | 6.11 |
| CHEMBL2268532 | 7-(2-PENTYNYLOXY)COUMARIN | Ki | = | 888.0 | nM | 6.05 |
| CHEMBL307341 | AURAPTENE | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL156692 | 7-PRENYLOXYCOUMARIN | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL221960 | — | Ki | = | 59000.0 | nM | 4.23 |
| CHEMBL156127 | UMBELLIPRENIN | KiL | = | 3.3 | nM | - |
| CHEMBL156127 | UMBELLIPRENIN | KiH | = | 1.6 | nM | - |