Assay Detail
Binding
CHEMBL4146837
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of equine serum BChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition measured every minute for 10 mins by Ellman's method
61
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel donepezil-like N-benzylpyridinium salt derivatives as AChE inhibitors and their corresponding dihydropyridine "bio-oxidizable" prodrugs: Synthesis, biological evaluation and structure-activity relationship.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 61 | 5.73 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95 | TACRINE | 4.0 | 1 | 8.49 |
| CHEMBL4177133 | — | — | 1 | 6.59 |
| CHEMBL4176179 | — | — | 1 | 6.47 |
| CHEMBL4159243 | — | — | 1 | 6.43 |
| CHEMBL4160115 | — | — | 1 | 6.38 |
| CHEMBL4161065 | — | — | 1 | 6.36 |
| CHEMBL4168037 | — | — | 1 | 6.31 |
| CHEMBL4166513 | — | — | 1 | 6.30 |
| CHEMBL4168987 | — | — | 1 | 6.22 |
| CHEMBL4173239 | — | — | 1 | 6.18 |
| CHEMBL4160696 | — | — | 4 | 5.78 |
| CHEMBL4165327 | — | — | 1 | 5.75 |
| CHEMBL4171568 | — | — | 1 | 5.69 |
| CHEMBL4173405 | — | — | 1 | 5.66 |
| CHEMBL4164981 | — | — | 1 | 5.65 |
| CHEMBL4170530 | — | — | 1 | 5.60 |
| CHEMBL4166464 | — | — | 1 | 5.58 |
| CHEMBL4165562 | — | — | 1 | 5.50 |
| CHEMBL4162993 | — | — | 1 | 5.49 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.47 |
| CHEMBL4170614 | — | — | 1 | 5.40 |
| CHEMBL4172797 | — | — | 1 | 5.38 |
| CHEMBL4173784 | — | — | 1 | 5.38 |
| CHEMBL4159880 | — | — | 1 | 5.37 |
| CHEMBL4174056 | — | — | 1 | 5.36 |
| CHEMBL4169887 | — | — | 1 | 5.27 |
| CHEMBL4162692 | — | — | 1 | 5.24 |
| CHEMBL4166141 | — | — | 1 | 5.22 |
| CHEMBL4172353 | — | — | 1 | 5.21 |
| CHEMBL4174372 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4177133 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL4176179 | — | IC50 | = | 341.0 | nM | 6.47 |
| CHEMBL4159243 | — | IC50 | = | 373.2 | nM | 6.43 |
| CHEMBL4160115 | — | IC50 | = | 412.0 | nM | 6.38 |
| CHEMBL4161065 | — | IC50 | = | 433.0 | nM | 6.36 |
| CHEMBL4168037 | — | IC50 | = | 489.0 | nM | 6.31 |
| CHEMBL4166513 | — | IC50 | = | 496.0 | nM | 6.30 |
| CHEMBL4168987 | — | IC50 | = | 596.0 | nM | 6.22 |
| CHEMBL4173239 | — | IC50 | = | 665.0 | nM | 6.18 |
| CHEMBL4160696 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL4165327 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL4160696 | — | IC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL4171568 | — | IC50 | = | 2035.0 | nM | 5.69 |
| CHEMBL4173405 | — | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL4164981 | — | IC50 | = | 2239.0 | nM | 5.65 |
| CHEMBL4170530 | — | IC50 | = | 2505.0 | nM | 5.60 |
| CHEMBL4166464 | — | IC50 | = | 2637.1 | nM | 5.58 |
| CHEMBL4165562 | — | IC50 | = | 3198.0 | nM | 5.50 |
| CHEMBL4162993 | — | IC50 | = | 3264.0 | nM | 5.49 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 3365.0 | nM | 5.47 |
| CHEMBL4170614 | — | IC50 | = | 4020.0 | nM | 5.40 |
| CHEMBL4160696 | — | IC50 | = | 3970.0 | nM | 5.40 |
| CHEMBL4173784 | — | IC50 | = | 4147.0 | nM | 5.38 |
| CHEMBL4172797 | — | IC50 | = | 4140.0 | nM | 5.38 |
| CHEMBL4159880 | — | IC50 | = | 4242.0 | nM | 5.37 |
| CHEMBL4174056 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4169887 | — | IC50 | = | 5361.0 | nM | 5.27 |
| CHEMBL4162692 | — | IC50 | = | 5775.0 | nM | 5.24 |
| CHEMBL4166141 | — | IC50 | = | 6010.0 | nM | 5.22 |
| CHEMBL4172353 | — | IC50 | = | 6090.0 | nM | 5.21 |
| CHEMBL4174372 | — | IC50 | = | 9115.0 | nM | 5.04 |
| CHEMBL4160696 | — | IC50 | = | 9070.0 | nM | 5.04 |
| CHEMBL4101303 | — | IC50 | = | 14295.0 | nM | 4.84 |
| CHEMBL4101303 | — | IC50 | = | 19925.0 | nM | 4.70 |
| CHEMBL4163077 | — | IC50 | - | — | - | |
| CHEMBL4173902 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4165973 | — | IC50 | - | — | - | |
| CHEMBL4162121 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4159705 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4170331 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4169938 | — | IC50 | - | — | - | |
| CHEMBL4170940 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4170921 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4167954 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4175814 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4162281 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4172950 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4175003 | — | IC50 | - | — | - | |
| CHEMBL4174452 | — | IC50 | > | 10000.0 | nM | - |