Assay Detail
Functional
CHEMBL4147066
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B infected in human MT4 cells assessed as protection against virus-induced cytopathic effect after 3 to 4 days by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Quinoxaline derivatives as new inhibitors of coxsackievirus B5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.57 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.70 |
| CHEMBL4159682 | — | — | 1 | 4.44 |
| CHEMBL4170313 | — | — | 1 | - |
| CHEMBL4173766 | — | — | 1 | - |
| CHEMBL4163061 | — | — | 1 | - |
| CHEMBL4163461 | — | — | 1 | - |
| CHEMBL4171360 | — | — | 1 | - |
| CHEMBL4168581 | — | — | 1 | - |
| CHEMBL4160658 | — | — | 1 | - |
| CHEMBL4165162 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4159682 | — | EC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL4170313 | — | EC50 | > | 48000.0 | nM | - |
| CHEMBL4173766 | — | EC50 | > | 28000.0 | nM | - |
| CHEMBL4163061 | — | EC50 | > | 60000.0 | nM | - |
| CHEMBL4163461 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4171360 | — | EC50 | > | 68000.0 | nM | - |
| CHEMBL4168581 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4160658 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4165162 | — | EC50 | > | 19000.0 | nM | - |