Assay Detail
ADMET
CHEMBL4148167
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Cytotoxicity against human A2780 cells assessed as growth inhibition after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Machine learning prioritizes synthesis of primaquine ureidoamides with high antimalarial activity and attenuated cytotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.64 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3330900 | — | — | 1 | 7.22 |
| CHEMBL3330912 | — | — | 1 | 6.00 |
| CHEMBL3330901 | — | — | 1 | 6.00 |
| CHEMBL43128 | PRIMAQUINE PHOSPHATE | 4.0 | 1 | 5.30 |
| CHEMBL4172194 | — | — | 1 | 4.85 |
| CHEMBL4167014 | — | — | 1 | 4.44 |
| CHEMBL4174900 | — | — | 1 | - |
| CHEMBL4168504 | — | — | 1 | - |
| CHEMBL4176362 | — | — | 1 | - |
| CHEMBL4161579 | — | — | 1 | - |
| CHEMBL4165001 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3330900 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3330912 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3330901 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL43128 | PRIMAQUINE PHOSPHATE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4172194 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4167014 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL4174900 | — | IC50 | - | — | - | |
| CHEMBL4168504 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4176362 | — | IC50 | - | — | - | |
| CHEMBL4161579 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4165001 | — | IC50 | - | — | - |