Assay Detail

CHEMBL4148203

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Trypanopcidal activity against Trypanosoma cruzi Y trypamastigotes after 24 hrs by Neubauer chamber or MTS dye based assay

ChEMBL ↗

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Target

Trypanosoma cruzi (CHEMBL368) ↗

Open DB target context

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Trypanosoma cruzi (CHEMBL368) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Trypanosoma cruzi

CHEMBL368

Anchored from Assay target.

Protein identity Trypanosoma cruzi

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Trypanosoma cruzi
Confidence	1 — Organism
Curated By	Intermediate

Target

Trypanosoma cruzi (CHEMBL368) ↗

Type	ORGANISM
Organism	Trypanosoma cruzi

Publication

Targeting polyamine transport in Trypanosoma cruzi.

Reigada C, Phanstiel O, Miranda MR, Pereira CA.
Eur J Med Chem (2018) 147 : 1 -6
PubMed 29421567 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.34	6.34

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL558390	—	—	1	6.34

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL558390	—	IC50	=	460.0	nM	6.34