Assay Detail
ADMET
CHEMBL4151827
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP3A4 (unknown origin) using midazolam as substrate
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.45 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4161754 | — | — | 1 | 5.80 |
| CHEMBL4163069 | — | — | 1 | 5.54 |
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4161754 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4163069 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 9500.0 | nM | 5.02 |