Assay Detail
Functional
CHEMBL4154514
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Inhibition of glucagon-mediated gluconeogenesis in mouse primary hepatocytes preincubated for 16 hrs followed by incubation under glucose free medium for 6 hrs by colorimetric assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Hepatocyte |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery and structure-activity relationships study of thieno[2,3-b]pyridine analogues as hepatic gluconeogenesis inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 4.73 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4161115 | — | — | 1 | 5.77 |
| CHEMBL4165573 | — | — | 1 | 5.10 |
| CHEMBL3092052 | — | — | 1 | 4.99 |
| CHEMBL4167923 | — | — | 1 | 4.91 |
| CHEMBL4169133 | — | — | 1 | 4.91 |
| CHEMBL4167617 | — | — | 1 | 4.91 |
| CHEMBL4161074 | — | — | 1 | 4.85 |
| CHEMBL4175779 | — | — | 1 | 4.84 |
| CHEMBL4167752 | — | — | 1 | 4.84 |
| CHEMBL4170991 | — | — | 1 | 4.81 |
| CHEMBL4160389 | — | — | 1 | 4.78 |
| CHEMBL4170208 | — | — | 1 | 4.75 |
| CHEMBL4164167 | — | — | 1 | 4.72 |
| CHEMBL4162938 | — | — | 1 | 4.66 |
| CHEMBL4176224 | — | — | 1 | 4.61 |
| CHEMBL4175489 | — | — | 1 | 4.61 |
| CHEMBL4177011 | — | — | 1 | 4.58 |
| CHEMBL4169042 | — | — | 1 | 4.52 |
| CHEMBL4172040 | — | — | 1 | 4.48 |
| CHEMBL4164487 | — | — | 1 | 4.47 |
| CHEMBL4165608 | — | — | 1 | 4.47 |
| CHEMBL4166391 | — | — | 1 | 4.42 |
| CHEMBL4173920 | — | — | 1 | 4.27 |
| CHEMBL4161894 | — | — | 1 | 4.18 |
| CHEMBL4174427 | — | — | 1 | - |
| CHEMBL4176445 | — | — | 1 | - |
| CHEMBL4169815 | — | — | 1 | - |
| CHEMBL4176188 | — | — | 1 | - |
| CHEMBL4172659 | — | — | 1 | - |
| CHEMBL4168999 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4161115 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4165573 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3092052 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4167923 | — | IC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL4169133 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL4167617 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL4161074 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL4175779 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL4167752 | — | IC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL4170991 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL4160389 | — | IC50 | = | 16800.0 | nM | 4.78 |
| CHEMBL4170208 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL4164167 | — | IC50 | = | 19100.0 | nM | 4.72 |
| CHEMBL4162938 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL4176224 | — | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL4175489 | — | IC50 | = | 24700.0 | nM | 4.61 |
| CHEMBL4177011 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL4169042 | — | IC50 | = | 30200.0 | nM | 4.52 |
| CHEMBL4172040 | — | IC50 | = | 33400.0 | nM | 4.48 |
| CHEMBL4164487 | — | IC50 | = | 34100.0 | nM | 4.47 |
| CHEMBL4165608 | — | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL4166391 | — | IC50 | = | 37800.0 | nM | 4.42 |
| CHEMBL4173920 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL4161894 | — | IC50 | = | 65300.0 | nM | 4.18 |
| CHEMBL4174427 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4176445 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4169815 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4176188 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4172659 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4168999 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4159521 | — | IC50 | > | 100000.0 | nM | - |