Assay Detail
Binding
CHEMBL4178554
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human 17beta-HSD1 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estrone and NADPH by scintillation counting method
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
17-beta-hydroxysteroid dehydrogenase type 1 (CHEMBL3181) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.84 | 7.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL312186 | — | — | 1 | 7.31 |
| CHEMBL6665 | — | — | 1 | 5.96 |
| CHEMBL129795 | ISOLIQUIRITIGENIN | — | 1 | 5.55 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 5.26 |
| CHEMBL375927 | (-)-DIHYDROGUAIARETICACID | — | 1 | 5.11 |
| CHEMBL324842 | ROSMARINIC ACID | — | 1 | - |
| CHEMBL4206971 | — | — | 1 | - |
| CHEMBL601464 | — | — | 1 | - |
| CHEMBL589354 | — | — | 1 | - |
| CHEMBL4205522 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL312186 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL6665 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL129795 | ISOLIQUIRITIGENIN | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL375927 | (-)-DIHYDROGUAIARETICACID | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL324842 | ROSMARINIC ACID | IC50 | - | — | - | |
| CHEMBL4206971 | — | IC50 | - | — | - | |
| CHEMBL601464 | — | IC50 | - | — | - | |
| CHEMBL589354 | — | IC50 | - | — | - | |
| CHEMBL4205522 | — | IC50 | - | — | - |