Assay Detail
Binding
CHEMBL4179166
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-8-OH-DPAT from serotonin 5-HT1A receptor in Sprague-Dawley rat brain cortex homogenates incubated for 30 mins by liquid scintillation spectrometry
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New 5-HT1A, 5HT2A and 5HT2C receptor ligands containing a picolinic nucleus: Synthesis, in vitro and in vivo pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 41 | 7.22 | 10.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4209954 | — | — | 1 | 10.34 |
| CHEMBL4208744 | — | — | 1 | 9.74 |
| CHEMBL3763633 | — | — | 1 | 9.46 |
| CHEMBL1202240 | — | — | 1 | 9.10 |
| CHEMBL4202926 | — | — | 1 | 7.75 |
| CHEMBL4214290 | — | — | 1 | 7.68 |
| CHEMBL4207997 | — | — | 1 | 7.49 |
| CHEMBL4211631 | — | — | 1 | 7.40 |
| CHEMBL4208886 | — | — | 1 | 7.36 |
| CHEMBL4210997 | — | — | 1 | 7.28 |
| CHEMBL4212565 | — | — | 1 | 7.26 |
| CHEMBL4210207 | — | — | 1 | 7.22 |
| CHEMBL4205121 | — | — | 1 | 7.17 |
| CHEMBL4215136 | — | — | 1 | 7.14 |
| CHEMBL4217522 | — | — | 1 | 7.13 |
| CHEMBL4204911 | — | — | 1 | 7.09 |
| CHEMBL4203722 | — | — | 1 | 7.07 |
| CHEMBL4214595 | — | — | 1 | 7.05 |
| CHEMBL4218931 | — | — | 1 | 6.98 |
| CHEMBL4218943 | — | — | 1 | 6.97 |
| CHEMBL4205281 | — | — | 1 | 6.86 |
| CHEMBL4217302 | — | — | 1 | 6.80 |
| CHEMBL4217285 | — | — | 1 | 6.79 |
| CHEMBL4206367 | — | — | 1 | 6.74 |
| CHEMBL4214059 | — | — | 1 | 6.67 |
| CHEMBL4218351 | — | — | 1 | 6.64 |
| CHEMBL4209660 | — | — | 1 | 6.57 |
| CHEMBL4204796 | — | — | 1 | 6.38 |
| CHEMBL4206107 | — | — | 1 | 6.35 |
| CHEMBL4205257 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4209954 | — | Ki | = | 0.046 | nM | 10.34 |
| CHEMBL4208744 | — | Ki | = | 0.183 | nM | 9.74 |
| CHEMBL3763633 | — | Ki | = | 0.344 | nM | 9.46 |
| CHEMBL1202240 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL4202926 | — | Ki | = | 17.9 | nM | 7.75 |
| CHEMBL4214290 | — | Ki | = | 20.8 | nM | 7.68 |
| CHEMBL4207997 | — | Ki | = | 32.7 | nM | 7.49 |
| CHEMBL4211631 | — | Ki | = | 40.1 | nM | 7.40 |
| CHEMBL4208886 | — | Ki | = | 44.1 | nM | 7.36 |
| CHEMBL4210997 | — | Ki | = | 52.7 | nM | 7.28 |
| CHEMBL4212565 | — | Ki | = | 55.4 | nM | 7.26 |
| CHEMBL4210207 | — | Ki | = | 59.5 | nM | 7.22 |
| CHEMBL4205121 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL4215136 | — | Ki | = | 71.6 | nM | 7.14 |
| CHEMBL4217522 | — | Ki | = | 74.8 | nM | 7.13 |
| CHEMBL4204911 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL4203722 | — | Ki | = | 85.6 | nM | 7.07 |
| CHEMBL4214595 | — | Ki | = | 88.7 | nM | 7.05 |
| CHEMBL4218931 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL4218943 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL4205281 | — | Ki | = | 138.0 | nM | 6.86 |
| CHEMBL4217302 | — | Ki | = | 158.0 | nM | 6.80 |
| CHEMBL4217285 | — | Ki | = | 161.0 | nM | 6.79 |
| CHEMBL4206367 | — | Ki | = | 181.0 | nM | 6.74 |
| CHEMBL4214059 | — | Ki | = | 215.0 | nM | 6.67 |
| CHEMBL4218351 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL4209660 | — | Ki | = | 267.0 | nM | 6.57 |
| CHEMBL4204796 | — | Ki | = | 412.0 | nM | 6.38 |
| CHEMBL4206107 | — | Ki | = | 443.0 | nM | 6.35 |
| CHEMBL4205257 | — | Ki | = | 495.0 | nM | 6.30 |
| CHEMBL4218142 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL4204620 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL4205290 | — | Ki | = | 599.0 | nM | 6.22 |
| CHEMBL4209138 | — | Ki | = | 1320.0 | nM | 5.88 |
| CHEMBL4207703 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4210519 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4218771 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4206623 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4210471 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4214076 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL4206752 | — | Ki | > | 10000.0 | nM | - |